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Zhou Yufeng


Zhou Yufeng
Assistant Professor
Tel: 6790 4482
Email: yfzhou@ntu.edu.sg
Office: N3.2-01-25
   
Education
  • PhD Duke University 2003
  • MS Nanjing University 1999
  • BS Nanjing University 1996

Biography
Prof Zhou is an Assistant Professor with the School of Mechanical & Aerospace Engineering since April 2010. He received the Ph.D. degree in Bioacoustics from Duke University in 2003, and the M.Sc. and B.Sc. degrees in Electrical Science and Engineering from Nanjing University in 1999 and 1996, respectively. Dr Zhou leads a multidisciplinary team focuses on ultrasound technology in biomedical applications. He is the PI of several projects funded by A*STAR SERC, NTU-NHG, MOE, NRF.

Research
  • Interest:
    Shock wave lithotripsy to break kidney stone, high-intensity focused ultrasound for cancer ablation and drug delivery, nondestructive evaluation/testing.
  • Projects:
    Investigation of Sonothrombolysis for the Treatment of Ischemic Stroke
    We investigated and applied transcranial ultrasound to dissolve the blood clot for stroke patients with the aid of microbubble and thrombolytic agent.
    [Mechanics of Machines Laboratory, Biomedical & Sports]
    Generation of Platelet-Rich Plasma by Ultrasound Standing Waves
    Ultrasound standing waves were applied to generate autologous platelet-rich plasma at a higher platelet concentration for wound healing and tissue regeneration with low cost-effectiveness ratio.
    [Mechanics of Machines Laboratory, Biomedical & Sports]
    Precise Visualization of Fine Needle Aspiration under Ultrasound Guidance Using MEMS Technique
    A mini acoustic actuator was manufactured with micro-electro-mechanical system technology to generate the interference with sonography for Precise localization of a needle tip.
    [Mechanics of Machines Laboratory, Biomedical & Sports]
    Improving the Technology of Shock Wave Lithotripsy
    A new lithotripter with the capability of dynamically adjusting the acoustic field during the stone fragmentation and reducing the bubble shielding effect was developed.
    [Mechanics of Machines Laboratory, Biomedical & Sports]
    Non-Invasive Removal of Benign Prostatic Hyperplasia by Extracorporeal Ultrasound under Imaging Guidance
    High-intensity focused ultrasound (HIFU) was used to generate tissue erosion and homeostasis simultaneously in the soft tissue under the guidance of B-mode sonography.
    [Mechanics of Machines Laboratory, Biomedical & Sports]
    Investigation of clogging in a micro-nozzle and its reduction by using ultrasound wave for 3D printing
    It aims to understand the clogging problem during 3D printing, to reduce it by acoustic vibration, and to monitor in real-time for the system control.
    [Biology Laboratory, Manufacturing]
    High-intensity focused ultrasound ablation of benign thyroid nodules using erosion mechanism
    We used image-guided high-intensity focused ultrasound (HIFU) treatment system to locally eliminate the thyroidal nodules and test the performance in animal experiments.
    [Mechanics of Machines Laboratory, Biomedical & Sports]
    Production of cell spheroid by ultrasound standing wave and application of ultrasound bioreactor in 3D vessel printing
    A novel solution is investigated for 3D tissue engineering, including generating the hydrogel-encapsulated cell spheroid, printing the skin structure, and simulating the vascularization by bioreactor.
    [Biology Laboratory, Manufacturing]
    Transmucosa Insuline Delivery by Ultrasound
    The ultrasound-mediated buccal transmucosa insulin delivery will be evaluated. If successful, it can provide a convenient, reliable, and noninvasive alternative to the needle injections.
    [Biology Laboratory, Biomedical & Sports]

Research Staff and Students under supervision

Research Staff
Name Title Email
Surasak Kasetsirikul Research Associate KSURASAK@ntu.edu.sg
Lei Yisheng Project Officer YSLEI@ntu.edu.sg

PhD Students
Name Project
Liu Chenhui Ultrasound Elastography in Lesion Diagnosis
Sriphutkiat Yannapol Ultrasound nozzle for 3D printing using MEMS Technology
Mao Yu Application of Ultrasound Technology on Urban Waste Treatment System
Wang Mingjun Energy Harvesting System using Piezoelectric Material

Selected Publications (click here for full publication list in PDF)
  • Y.F. Zhou, J. Qin, and P. Zhong, Characteristics of the secondary bubble cluster produced by an electrohydraulic shock wave lithotripter, Ultrasound in Medicine and Biology, 38(4), 601-610, 2012.
  • Y.F. Zhou, Generation of uniform lesions in high intensity focused ultrasound ablation, Ultrasonics, 53(2), 495-505, 2013.
  • Y.F. Zhou and X.B. Gao, Variations of bubble cavitation and temperature elevation during lesion formation by high-intensity focused ultrasound, Journal of the Acoustical Society of America, 134(2), 1683-1694, 2013.
  • Y.F. Zhou, Suresh Kanna Murugappan, Vijay Kumar Sharma,  Effect of clot aging and cholesterol content on ultrasound-assisted thrombolysis, Translational Stroke Research, 5:5, 627-634, 2014.
  • Yufeng Zhou, Yak-Nam Wang, Navid Farr, Jasmine Zia, Hong Chen, Bong Min Ko, Tatiana Khokhlova, Tong Li, and Joo Ha Hwang, Enhancement of nanoparticle delivery by pulsed-high intensity focused ultrasound (p-HIFU): A parameter exploration, Ultrasound in Medicine and Biology, 42(4), 956-963, 2016.
  • Mingjun Wang and Yufeng Zhou, Simulation of nonlinear acoustic field and thermal pattern of phased-array high-intensity focused ultrasound (HIFU), International Journal of Hyperthermia, 32(5), 569-582, 2016.
  • Jen-Chieh Wang and Yufeng Zhou, Shifting the Split Reflectors to Enhance Stone Fragmentation of Shock Wave Lithotripsy, Ultrasound in Medicine and Biology, 42(8), 1876-1889, 2016.
  • Yue Wu, Murugappan Suresh Kanna, Chenhui Liu, Yufeng Zhou, Generation of autologous platelet-rich plasma by the ultrasonic standing waves, IEEE transactions on Biomedical Engineering, 63(8), 1642-1652, 2016.
  • Yufeng Zhou and Xiaobin Wilson Gao, Effect of hydrodynamic cavitation in the tissue erosion by pulsed high-intensity focused ultrasound (pHIFU), Physics in Medicine and Biology, 61(18), 6651-6667, 2016.
  • Wenjing Yang and Yufeng Zhou, Effect of pulse repetition frequency of high-intensity focused ultrasound on in vitro thrombolysis, Ultrasonics Sonochemistry, 35, 152-160, 2017.

Teaching
  • Introduction to Electrical Circuits & Electronic Devices
  • Engineering Measurements
  • Dynamics
  • An Introduction to Engineering and Practices
  • Engineering Mathematics